Patients who took PPIs had a 96% increased risk of developing kidney failure and a 28% increased risk of chronic kidney disease compared to the patients who took the histamine H2 receptor blockers.
Earlier studies have shown that taking PPIs have been linked to acute interstitial nephritis, also a problem that may be likely to end in kidney failure. A study that ran online in JAMA in January also found a link between PPIs and a higher risk of chronic kidney disease, also known as CKD.
Like this study, it also was observational and doesn’t provide evidence of causality, but as the earlier study said, “even a casual relationship between PPI use and CKD could have a considerable public health effect given the widespread extent of use.”
Other side effects from taking PPIs include an increased risk of pneumonia, double the risk of infection from C. difficile and a small risk of osteoporosis, earlier studies have shown.
The authors of this research suggest that PPIs are overprescribed. Previous research, including a 2008 study and others have shown the same. The authors of the new study conclude if a person has a prescription for a PPI, it should be used sparingly and only taken for a short period of time.
Popular medications linked to higher risk of kidney failure #JHedzWorlD
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